Avoid using splash pages:
A splash page is usually a page people use on their websites as an introduction.The page generally contains an image on with a big click here to enter sign.It is better to avoid splash screens as it is just creating additional work for your visitor as they have to click the mouse button an extra time just to view the content of your site.

Use simple navigation:
Always ensure that your navigation is simple and don’t make it too complicated.If people find the navigation difficult they will get frustrated and leave the site soon.
Avoid using too many scripts and flash based menus, as some browsers may not support
scripts.

Keep your paragraphs to shorter lengths:
While providing relative and informative content,also ensure that the paragraphs are of shorter length.It is much easier for a visitor to read if the paragraphs are of shorter length.

Style it with CSS:
One of the best practices while building your site is to use CSS.It is the best way to adjust the font and size settings of the websites efficiently.

Test your website with all browsers:
A website looks different in each browser. Hence it is extremely important to test a site in maximum number of browsers.

check out this forum googlecommunity.com/forum/web-design-coding-programming-forum/39147-basic-web-design-tips.html to know more